Table 1

Linkage Statistics for Striatal Volume and Neuron Number

Trait

Marker

Chr

LRS†

%Var

P

Add**

Dom


Striatal Volume

D1Mit15

1

6.3

11

0.04361

1.55

1.19

(mm3)

D5Mit338

5

6.4

11

0.03984

-1.00

-2.13

D6Mit201

6

7.7

14

0.02161

0.90

2.88

D10Mit106

10

11.4

23

0.00342

2.54

1.09

*

D10Mit186

10

17.5

35

0.00016

2.34

1.46

D10Mit209

10

14.8

30

0.00061

2.15

1.26

D11Mit263

11

6.6

12

0.03675

1.39

1.67

D13Mit64

13

7.5

14

0.02330

0.29

2.72


Striatal Volume

D10Mit106

10

6.8

12

0.03316

0.71

1.19

Residual

D13Mit108

13

6.7

12

0.03496

0.30

1.45


Striatal Neuron

D1Mit65

1

9.6

19

0.00809

-57,000

-229,000

Number

D10Mit186

10

8.3

16

0.01593

96,000

181,000

D10Mit209

10

6.8

13

0.03296

86,000

171,000

D15Mit220

15

8.7

17

0.01275

128,000

177,000

D19Mit123

19

11.9

24

0.00263

198,000

-126,000


Striatal Neuron

D1Mit65

1

7.2

13

0.02697

-33,000

-189,000

Number Residual

D13Mit108

13

6.5

11

0.03925

-46,000

173,000

D15Mit220

15

7.4

14

0.02533

110,000

147,000

D16Mit130

16

6.8

12

0.03270

-99,000

206,000

*

D19Mit123

19

15.0

30

0.00055

201,000

-94,000


Brain Volume

D10Mit186

10

12.3

25

0.00217

28.09

8.82

(mm3)

D10Mit209

10

10.0

20

0.00672

25.12

5.86

D10Mit233

10

10.1

22

0.00634

31.30

8.62

D18Mit20

18

14.8

30

0.00061

36.76

-0.34

D18Mit120

18

12.2

25

0.00219

28.80

-16.27


Brain-Striatal

D10Mit186

10

11.4

23

0.00328

25.8

6.9

Volume

D10Mit209

10

9.3

18

0.00965

23.0

4.1

D10Mit233

10

9.3

20

0.00935

28.5

6.5

¶D18Mit20

18

15.1

31

0.00053

34.7

-1.7

D18Mit120

18

12.8

26

0.00168

27.2

-16.4


** Alleles inherited from BXD5 that increase a value are defined as positive additive effects. † LRS values can be converted to LOD scores by dividing by 4.6. Previously described QTL for brain weight [56]. Column headings:Trait, the phenotype used in linkage analysis; Marker, the symbol of the microsatellite loci used to genotype mice; Chr, the chromosome on which the marker is located; LRS is the likelihood ratio statistic (4.6 x the LOD score); %Var is the percentage of the total phenotypic variance apparently accounted for by differences in genotype in the an interval defined by the marker; P, the point-wise probability that the linkage is a false positive. Add and Dom are estimates of the additive and dominance effects of genetic variation. Units are the same as those of the traits (volume in mm3 or numbers of cells). The two bold loci marked with asterisks achieve genome-wide significance in this sample population.

Rosen and Williams BMC Neuroscience 2001 2:5   doi:10.1186/1471-2202-2-5

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