|
Linkage Statistics for Striatal Volume and Neuron Number |
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| Trait |
Marker |
Chr |
LRS† |
%Var |
P |
Add** |
Dom |
|
|
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| Striatal Volume |
D1Mit15 |
1 |
6.3 |
11 |
0.04361 |
1.55 |
1.19 |
| (mm3) |
D5Mit338 |
5 |
6.4 |
11 |
0.03984 |
-1.00 |
-2.13 |
| D6Mit201 |
6 |
7.7 |
14 |
0.02161 |
0.90 |
2.88 |
|
| D10Mit106 |
10 |
11.4 |
23 |
0.00342 |
2.54 |
1.09 |
|
| * |
D10Mit186 |
10 |
17.5 |
35 |
0.00016 |
2.34 |
1.46 |
| D10Mit209 |
10 |
14.8 |
30 |
0.00061 |
2.15 |
1.26 |
|
| D11Mit263 |
11 |
6.6 |
12 |
0.03675 |
1.39 |
1.67 |
|
| D13Mit64 |
13 |
7.5 |
14 |
0.02330 |
0.29 |
2.72 |
|
|
|
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| Striatal Volume |
D10Mit106 |
10 |
6.8 |
12 |
0.03316 |
0.71 |
1.19 |
| Residual |
D13Mit108 |
13 |
6.7 |
12 |
0.03496 |
0.30 |
1.45 |
|
|
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| Striatal Neuron |
D1Mit65 |
1 |
9.6 |
19 |
0.00809 |
-57,000 |
-229,000 |
| Number |
D10Mit186 |
10 |
8.3 |
16 |
0.01593 |
96,000 |
181,000 |
| D10Mit209 |
10 |
6.8 |
13 |
0.03296 |
86,000 |
171,000 |
|
| D15Mit220 |
15 |
8.7 |
17 |
0.01275 |
128,000 |
177,000 |
|
| D19Mit123 |
19 |
11.9 |
24 |
0.00263 |
198,000 |
-126,000 |
|
|
|
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| Striatal Neuron |
D1Mit65 |
1 |
7.2 |
13 |
0.02697 |
-33,000 |
-189,000 |
| Number Residual |
D13Mit108 |
13 |
6.5 |
11 |
0.03925 |
-46,000 |
173,000 |
| D15Mit220 |
15 |
7.4 |
14 |
0.02533 |
110,000 |
147,000 |
|
| D16Mit130 |
16 |
6.8 |
12 |
0.03270 |
-99,000 |
206,000 |
|
| * |
D19Mit123 |
19 |
15.0 |
30 |
0.00055 |
201,000 |
-94,000 |
|
|
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| Brain Volume |
D10Mit186 |
10 |
12.3 |
25 |
0.00217 |
28.09 |
8.82 |
| (mm3) |
D10Mit209 |
10 |
10.0 |
20 |
0.00672 |
25.12 |
5.86 |
| D10Mit233 |
10 |
10.1 |
22 |
0.00634 |
31.30 |
8.62 |
|
| D18Mit20 |
18 |
14.8 |
30 |
0.00061 |
36.76 |
-0.34 |
|
| D18Mit120 |
18 |
12.2 |
25 |
0.00219 |
28.80 |
-16.27 |
|
|
|
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| Brain-Striatal |
D10Mit186 |
10 |
11.4 |
23 |
0.00328 |
25.8 |
6.9 |
| Volume |
D10Mit209 |
10 |
9.3 |
18 |
0.00965 |
23.0 |
4.1 |
| D10Mit233 |
10 |
9.3 |
20 |
0.00935 |
28.5 |
6.5 |
|
| ¶D18Mit20 |
18 |
15.1 |
31 |
0.00053 |
34.7 |
-1.7 |
|
| D18Mit120 |
18 |
12.8 |
26 |
0.00168 |
27.2 |
-16.4 |
|
|
** Alleles inherited from BXD5 that increase a value are defined as positive additive effects. † LRS values can be converted to LOD scores by dividing by 4.6. Previously described QTL for brain weight [56]. Column headings:Trait, the phenotype used in linkage analysis; Marker, the symbol of the microsatellite loci used to genotype mice; Chr, the chromosome on which the marker is located; LRS is the likelihood ratio statistic (4.6 x the LOD score); %Var is the percentage of the total phenotypic variance apparently accounted for by differences in genotype in the an interval defined by the marker; P, the point-wise probability that the linkage is a false positive. Add and Dom are estimates of the additive and dominance effects of genetic variation. Units are the same as those of the traits (volume in mm3 or numbers of cells). The two bold loci marked with asterisks achieve genome-wide significance in this sample population. | |||||||
Rosen and Williams BMC Neuroscience 2001 2:5 doi:10.1186/1471-2202-2-5 |
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