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Open Access Highly Accessed Research article

Compulsive checking behavior of quinpirole-sensitized rats as an animal model of Obsessive-Compulsive Disorder(OCD): form and control

Henry Szechtman1*, Michael J Eckert1, Wai S Tse1, Jonathan T Boersma1, Carlo A Bonura1, Jessica Z McClelland1, Kirsten E Culver1 and David Eilam2

Author affiliations

1 Dept of Psychiatry and Behavioural Neurosciences, McMaster University, Canada

2 Dept of Zoology, Tel-Aviv University, Israel

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Citation and License

BMC Neuroscience 2001, 2:4  doi:10.1186/1471-2202-2-4

Published: 12 April 2001

Abstract

Background

A previous report showed that the open field behavior of rats sensitized to the dopamine agonist quinpirole satisfies 5 performance criteria for compulsive checking behavior. In an effort to extend the parallel between the drug-induced phenomenon and human obsessive-compulsive disorder (OCD), the present study investigated whether the checking behavior of quinpirole rats is subject to interruption, which is an attribute characteristic of OCD compulsions. For this purpose, the rat's home-cage was placed into the open field at the beginning or the middle of a 2-hr test.

Results

Introduction of the home-cage reduced checking behavior, as rats stayed inside the cage. After 40 min, checking resurfaced, as quinpirole rats exited the home-cage often. An unfamiliar cage had no such effects on quinpirole rats or saline controls.

Conclusions

Checking behavior induced by quinpirole is not irrepressible but can be suspended. Results strengthen the quinpirole preparation as an animal model of OCD compulsive checking.