Production of cytokines by CNS infiltrating cells stimulated with MOG or SAC. C57BL/6 mice were infected with S. aureus strains, and 3 days later, they were subjected to EAE induction. Cytokine production was tested 19 days after EAE induction (acute phase) in CNS cell cultures. IFN-γ (a), IL-17 (b), IL-5 (c) and IL-10 (d) production were assayed in cultures that were re-stimulated in vitro with MOG. IFN-γ (e), IL-17 (f), IL-5 (g) and IL-10 (h) production were assayed in cultures that were re-stimulated in vitro with SAC. Data are expressed as the mean ± SE of 5-12 mice. Different letters represent significant differences between groups. Statistical analysis (ANOVA or ANOVA on Ranks with Dunn’s method) indicates significant differences between EAE and both infected groups, p< 0.05.
França et al. BMC Neuroscience 2014 15:8 doi:10.1186/1471-2202-15-8