MRC2 neuropathology. Histological features of MRC2 prion transmission to Cx3cr1-/-(A-E) and wild type control (F-J) mice. Panels A and F show the global distribution of disease-associated PrP using anti-PrP monoclonal antibody ICSM35. Panels B, C, G and H show staining of microglia with Iba-1 in the hippocampus (B, G) and the thalamus (C, H). Panels D, E, I and J are stained with haematoxylin and eosin (H&E) to visualise spongiosis and neuronal loss in the hippocampus. Boxes show where the higher power images have been taken and arrows highlight apoptotic cells. Overall, no differences are seen between Cx3cr1-/- and wild type mice. Scale bar corresponds to 2mm (A, F), 400 μm (B, C, D, G, H, I) or 100 μm (E, J).
Grizenkova et al. BMC Neuroscience 2014 15:44 doi:10.1186/1471-2202-15-44