Table 2

Mean ± S.D and independent t-test for HSP-70, GABA, serotonin, dopamine, oxytocin, and Interferon μ inducible protein 16 (IFI-16) in neurointoxicated, melatonin protected and treated rat pups compared to healthy control
Parameters Group N Mean ± S.D. P value
HSP70 (ng/ml) Control 8 10.563 ± 0.370
PA 8 9.400 ± 0.490 0.001a
Melatonin-protected group 8 10.043 ± 0.454 0.030a
Melatonin-treated group 8 10.083 ± 0.445 0.048a
GABA (ng/10 mg) Control 8 109.100 ± 4.666
PA 8 67.183 ± 3.125 0.001a
Melatonin-protected group 8 83.160 ± 4.668 0.01a
Melatonin-treated group 8 75.144 ± 2.694 0.001a
Serotonin (ng/ml) Control 8 0.073 ± 0.017
PA 8 0.047 ± 0.011 0.004a
Melatonin-protected group 8 0.101 ± 0.019 0.011a
Melatonin-treated group 8 0.099 ± 0.019 0.016a
Dopamine (ng/ml) Control 8 136.250 ± 18.468
PA 8 106.875 ± 12.229 0.002a
Melatonin-protected group 8 173.125 ± 29.873 0.010a
Melatonin-treated group 8 164.375 ± 23.213 0.018a
Oxytocin (Pg/ml) Control 8 89.750 ± 4.464
PA 8 84.500 ± 4.751 0.039a
Melatonin-protected group 8 97.750 ± 8.714 0.037a
Melatonin-treated group 8 100.750 ± 6.409 0.001a
Interferon μ inducible protein 16 (Pg/ml) Control 8 833.750 ± 63.906
PA 8 768.750 ± 53.033 0.044a
Melatonin-protected group 8 921.250 ± 71.801 0.022a
Melatonin-treated group 8 922.500 ± 79.057 0.027a

aSignificant level between the studied groups compared to control when P < 0.05.

Al-Ghamdi et al.

Al-Ghamdi et al. BMC Neuroscience 2014 15:34   doi:10.1186/1471-2202-15-34

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