Table 4

Twenty KEGG and PANTHER pathways applied to the 500 hypermethylated genes in the thalamus
Category Pathway Count Fold Benjamini
Enrichment P value P value
KEGG_PATHWAY Long-term potentiation 9 5.270 2.58 × 10-4 0.033
KEGG_PATHWAY MAPK signaling pathway 16 2.475 0.002 0.108
PANTHER_PATHWAY Alzheimer disease-amyloid secretase pathway 9 3.872 0.002 0.147
KEGG_PATHWAY Long-term depression 7 3.985 0.008 0.283
KEGG_PATHWAY GnRH signaling pathway 8 3.380 0.009 0.250
KEGG_PATHWAY Calcium signaling pathway 11 2.360 0.017 0.360
KEGG_PATHWAY Vascular smooth muscle contraction 8 2.732 0.026 0.433
KEGG_PATHWAY Wnt signaling pathway 9 2.476 0.028 0.405
KEGG_PATHWAY Melanogenesis 7 2.869 0.034 0.428
PANTHER_PATHWAY TGF-beta signaling pathway 10 2.080 0.046 0.876
KEGG_PATHWAY Ubiquitin mediated proteolysis 8 2.411 0.046 0.496
PANTHER_PATHWAY Endogenous_cannabinoid_signaling 4 4.832 0.047 0.757
PANTHER_PATHWAY PDGF signaling pathway 11 1.930 0.052 0.698
KEGG_PATHWAY Glycerophospholipid metabolism 5 3.059 0.078 0.654
PANTHER_PATHWAY Endothelin signaling pathway 7 2.290 0.080 0.772
PANTHER_PATHWAY Notch signaling pathway 5 2.963 0.084 0.727
PANTHER_PATHWAY Metabotropic glutamate receptor group II pathway 5 2.908 0.088 0.691
KEGG_PATHWAY Neurotrophin signaling pathway 7 2.207 0.095 0.692
PANTHER_PATHWAY Ionotropic glutamate receptor pathway 5 2.804 0.098 0.682
KEGG_PATHWAY N-Glycan biosynthesis 4 3.564 0.100 0.679

Weng et al.

Weng et al. BMC Neuroscience 2014 15:31   doi:10.1186/1471-2202-15-31

Open Data