Effect of quetiapine on c-Fos expression in C57BL/6 mouse prefrontal cortex and striatum. Representative blots (A) prefrontal cortex and (C) striatum indicate immunoreactive bands of c-Fos (upper panel) and β-Actin (lower panel) expression following quetiapine (5 mg/kg) treatment and correspond with the bar graph below. (B) Quetiapine treatment (5 mg/kg) over a 24 hr period - prefrontal cortex. (D) Quetiapine treatment (5 mg/kg) over a 24 hr period - striatum. At each time point treated samples were expressed relative to vehicle control standardized to 100 percent. Data represent the mean ± SEM of at least four mice per experimental group. ***p < 0.001, statistical differences between tissue in the absence (vehicle) and presence of quetiapine are indicated.
Pereira et al. BMC Neuroscience 2014 15:30 doi:10.1186/1471-2202-15-30