Full-length, transgene-derived amyloid precursor protein (APP) levels in isolated muscle. Representative Western blots of homogenates isolated from the soleus (sol), plantaris (plan), gastrocnemius (gast), and tibialis anterior (TA) muscles of App(swe)/PS1(ΔE9) (DTG) and non-transgenic (NTG) male mice (3–18 mo) probed with 6E10 antibody. Transgene-derived, full-length APP (~106 Kd) is observed in DTG mice at all ages tested. There are no observable bands at this molecular weight in the NTG mice. Within an age group, there are differences in band intensity of the full-length APP between the four muscle groups tested: Plan > TA/Gast > Sol.
Schuh et al. BMC Neuroscience 2014 15:24 doi:10.1186/1471-2202-15-24