Table 1

The analyzed G protein-coupled receptors
Number Neurotransmitter Receptor Gene Coupling Median inter-subject correlation
1 Glutamate mGluR1 GRM1 Gq 0.91
2 Glutamate mGluR2 GRM2 Gi 0.37
3 Glutamate mGluR3 GRM3 Gi 0.82
4 Glutamate mGluR4 GRM4 Gi 0.94
5 Glutamate mGluR5 GRM5 Gq 0.92
6 Glutamate mGluR6 GRM6 Gi 0.12
7 Glutamate mGluR7 GRM7 Gi 0.89
8 Glutamate mGluR8 GRM8 Gi 0.45
9 GABA GABABR1 GABBR1 Gi 0.78
10 GABA GABABR2 GABBR2 Gi 0.89
11 Dopamine D1 DRD1 Gs 0.91
12 Dopamine D2 DRD2 Gi 0.89
13 Dopamine D3 DRD3 Gi 0.69
14 Dopamine D4 DRD4 Gi 0.03
15 Dopamine D5 DRD5 Gs 0.83
16 Adrenergic α1A ADRA1A Gq 0.76
17 Adrenergic α1B ADRA1B Gq 0.87
18 Adrenergic α1D ADRA1D Gq 0.79
19 Adrenergic α2A ADRA2A Gi 0.62
20 Adrenergic α2B ADRA2B Gi 0.31
21 Adrenergic α2C ADRA2C Gi 0.64
22 Adrenergic β1 ADRB1 Gs 0.59
23 Adrenergic β2 ADRB2 Gs 0.67
24 Adrenergic β3 ADRB3 Gs/Gi 0.15
25 Serotonin 5-HT1A HTR1A Gi 0.86
26 Serotonin 5-HT1B HTR1B Gi 0.38
27 Serotonin 5-HT1D HTR1D Gi 0.79
28 Serotonin 5-HT1E HTR1E Gi 0.82
29 Serotonin 5-HT1F HTR1F Gi 0.90
30 Serotonin 5-HT2A HTR2A Gq 0.95
31 Serotonin 5-HT2B HTR2B Gq 0.12
32 Serotonin 5-HT2C HTR2C Gq 0.92
33 Serotonin 5-HT4 HTR4 Gs 0.89
34 Serotonin 5-HT5A HTR5A Gs 0.89
35 Serotonin 5-HT6 HTR6 Gs 0.21
36 Serotonin 5-HT7 HTR7 Gs 0.89
37 Cholinergic M1 CHRM1 Gq 0.53
38 Cholinergic M2 CHRM2 Gi 0.91
39 Cholinergic M3 CHRM3 Gq 0.96
40 Cholinergic M4 CHRM4 Gi 0.53
41 Cholinergic M5 CHRM5 Gq 0.63
42 Histamine H1 HRH1 Gq 0.82
43 Histamine H2 HRH2 Gs 0.69
44 Histamine H3 HRH3 Gi 0.66
45 Histamine H4 HRH4 Gi 0.09
46 Bradykinin B1 BDKRB1 Gq 0.69
47 Bradykinin B2 BDKRB2 Gq 0.61
48 Cholecystokinin CCK1 CCKAR Gq 0.46
49 Cholecystokinin CCK2 CCKBR Gq 0.94
50 CRH CRF1 CRHR1 Gs 0.65
51 CRH CRF2 CRHR2 Gs 0.35
52 Galanin Gal1 GALR1 Gi 0.74
53 Galanin Gal2 GALR2 Gi/Gq 0.54
54 Galanin Gal3 GALR3 Gi 0.08
55 MCH MCH1 MCHR1 Gi 0.70
56 MCH MCH2 MCHR2 Gq 0.93
57 MSH MC1 MC1R Gs 0.73
58 MSH MC2 MC2R Gs 0.10
59 MSH MC3 MC3R Gs 0.40
60 MSH MC4 MC4R Gs 0.49
61 MSH MC5 MC5R Gs 0.04
62 NPY Y1 NPY1R Gi 0.91
63 NPY Y2 NPY2R Gi 0.74
64 NPY Y4 PPYR1 Gi 0.18
65 NPY Y5 NPY5R Gi 0.86
66 NPY Y6 NPY6R Gi 0.36
67 Neurotensin NT1 NTSR1 Gq 0.48
68 Neurotensin NT2 NTSR2 Gq 0.81
69 Opioid μ OPRM1 Gi 0.84
70 Opioid δ OPRD1 Gi 0.25
71 Opioid κ OPRK1 Gi 0.67
72 Nociceptin ORL-1 OPRL1 Gi 0.81
73 Orexin OX1 HCRTR1 Gq 0.82
74 Orexin OX2 HCRTR1 Gi 0.64
75 Oxytocin OT OXTR Gq 0.75
76 Somatostatin SST1 SSTR1 Gi 0.81
77 Somatostatin SST2 SSTR2 Gi 0.91
78 Somatostatin SST3 SSTR3 Gi 0.28
79 Somatostatin SST4 SSTR4 Gi 0.07
80 Somatostatin SST5 SSTR5 Gi 0.16
81 Tachykinin NK1 TACR1 Gq 0.55
82 Tachykinin NK2 TACR2 Gq 0.34
83 Tachykinin NK3 TACR3 Gq 0.81
84 TRH TRHR TRHR Gq 0.79
85 VIP VPAC1 VIPR1 Gs 0.86
86 VIP VPAC2 VIPR2 Gs 0.77
87 Vasopressin V1a AVPR1A Gq 0.34
88 Vasopressin V1b AVPR1B Gq 0.04
89 Vasopressin V2 AVPR2 Gs 0.16
90 Adenosine A1 ADORA1 Gi 0.66
91 Adenosine A2A ADORA2A Gs 0.87
92 Adenosine A2B ADORA2B Gs 0.57
93 Adenosine A3 ADORA3 Gi 0.37
94 Purine P2Y1 P2RY1 Gq 0.72
95 Purine P2Y2 P2RY2 Gi/Gq 0.37
96 Purine P2Y4 P2RY4 Gi/Gq 0.00
97 Purine P2Y6 P2RY6 Gq 0.32
98 Purine P2Y11 P2RY11 Gq 0.34
99 Cannabinoid CB1 CNR1 Gi 0.90
100 Cannabinoid CB2 CNR2 Gi 0.46

The inter-subject correlations were obtained from 6 subjects (15 cross-correlations).

Janušonis

Janušonis BMC Neuroscience 2014 15:16   doi:10.1186/1471-2202-15-16

Open Data