No OL differentiation in E17.5 Olig1 null spinal cord. Fluorescence in situ hybridization for myelin basic protein (Mbp) (A,C,E,G) or proteolipid protein (Plp) (B,D,F,H) gene transcripts was performed on sections of E17.5 mouse spinal cords. No Mbp- or Plp-positive cells were detected in the circumferential white matter of Olig1(-/-) or Olig(-/-),Olig2(Tg) cords (C,D and G,H respectively) compared to cognate Olig1(+/-) controls (A,B and E,F). Scale bar: 80 μm.
Paes de Faria et al. BMC Neuroscience 2014 15:12 doi:10.1186/1471-2202-15-12