WGCNA generated correlations containing transcription factors found in the module correlated with the postpartum phenotype. Of the two modules generated using WGCNA, one was highly correlated with the postpartum phenotype. All gene-to-gene correlations involving transcription factors were selected from the module associated with the postpartum phenotype, and the network was visualized using Cytoscape. Edge width and size are proportional to the weight of the correlation between two genes. Blue nodes with bolded text are highly significant (nominal p < 0.01) transcription factors, co-factors, and chromatin remodeling factors correlated to a subset of other variable genes (nominal p < 0.05) from the microarray. Bolded text with gray nodes are genes found in other enriched gene lists, and include genes linked to mental health disorders, CNS development, and ion channel activity. Some transcription factors were also found in gene lists linked to mental health disorders, CNS development, and ion channel activity, but have been marked as transcription factors for this visualization. A full list of nodes and the weighted interactions for these genes can be found in Additional file 4.
Driessen et al. BMC Neuroscience 2014 15:11 doi:10.1186/1471-2202-15-11