Overview of MSET procedure, and enrichment values for mental health disorder realted gene lists. (A) Overview of the MSET procedure with examples of gene lists selected for our analysis. After entering the desired number of randomizations to perform, a probability density distribution of matches to the gene list of interest is generated. The second blue arrow shows how many matches to the gene list of interest were found in our significant microarray results and the corresponding enrichment value. The y-axis represents the probability of matches between gene lists of interest and 10,000 randomly generated lists, and the x-axis denotes the number of genes of interest found in each randomly produced list. (B) Enrichment values for all gene lists tested relating to ASD, BPD, depression, and schizophrenia, and the control lists from GAD associated with arthritis, liver disease, and Parkinson’s disease. P-values were shaded based on their degree of significance, with green being the most significant and red being the least significant. MSET analysis detected overall enrichment for ASD, depression, and schizophrenia related genes in the top 734 genes from the microarray. Three of the four BPD associated gene lists revealed significant enrichment within the microarray results, but only a trend toward significance was found using the GWAS list. The control lists were non-significant, providing evidence for the specificity of MSET analysis. (C) Examples of the probability density distribution for four gene lists relating to ASD, BPD, schizophrenia, and Parkinson’s Disease. Arrows mark the number of genes of interest found in the top 734 genes from the microarray data.
Driessen et al. BMC Neuroscience 2014 15:11 doi:10.1186/1471-2202-15-11