Quantification of mitochondrial shape changes in secondary degeneration +/- R/NIR-IT. Mean ratios of diameters did not change with either injury or R/NIR-IT in axons (A) or glia (B). At day 1, there was no change in mitochondrial profile shape in axons (C), but a higher probability of more elliptical profiles (signified by larger ratios) was observed in glia (D). Following R/NIR-IT, the distributions of mitochondrial profile shape in glia were not significantly different from normal. At day 7 following injury, the distribution of mitochondrial profile shape was not different compared to normal in axons (E), but again a higher cumulative probability of more elliptical profiles in glia was observed (F); a change which was no longer detected after R/NIR-IT. *Significantly different at p ≤ 0.05.
Cummins et al. BMC Neuroscience 2013 14:98 doi:10.1186/1471-2202-14-98