Changes in mitochondrial profile cross-sectional area in secondary degeneration +/− R/NIR-IT. Mean area did not change with either injury or R/NIR-IT in axons (A) or glia (B). At day 1 after PT, mitochondrial profiles with smaller areas became more frequent in axons, and this was no longer observed following R/NIR-IT at this time (C). There were no changes in the distributions of glial mitochondria at day 1 (D). At day 7, there was no change in the distribution of area of axonal mitochondrial profiles (E). R/NIR-IT resulted in an increased cumulative probability of mitochondria with smaller cross-sectional areas compared to PT day 7 in glia, however neither the distributions of injured animals (PT) or R/NIR-IT animals (PT 670 nm) were different from normal (F). *Significantly different at p ≤ 0.05.
Cummins et al. BMC Neuroscience 2013 14:98 doi:10.1186/1471-2202-14-98