Neuroprotective effects of B355252 against glutamate-induced toxicity. HT-22 cells were treated with or without glutamate and the indicated concentrations of B355252 and analyzed with the MTT assay (A), or a fluorescent viability assay (B, C, D). (A). B355252 conferred significant dose-dependent protection against glutamate toxicity compared to the untreated control. B355252 also displayed cell proliferative effect in the absence of glutamate (*p<0.05, ***p<0.001 compared to glutamate-treated cells; ###p<0.001, +++p<0.001 compared to control). Representative morphology of glutamate treated cells (B), cells protected from glutamate toxicity by B355252 (C), and untreated control cells (D).
Gliyazova et al. BMC Neuroscience 2013 14:93 doi:10.1186/1471-2202-14-93