Microinjection of a D2R antagonist modified the depression of nociceptive responses induced by HFS. A: Time course of procedure is presented. Pre1: Pre-HFS (before sulpiride microinjection). Pre2: Pre-HFS (after sulpiride microinjection). B: The top trace represents ECoG. The second trace is multiple unit discharges evoked by mechanical stimulation. The third trace represents single unit responses selected by cluster analysis from multiple units in the top line. The bottom trace represents a pressure curve. The D2R antagonist, sulpiride, impaired effects of HFS delivered to the VTA. C, D: At 10 and 30 min after HFS, a D2R antagonist blocked the depression of nociceptive responses induced by HFS to the VTA to a statistically significant extent. Mean changes in the duration (C) and frequency (D) of responses are presented. Error bars represent S.E. n=9.
Sogabe et al. BMC Neuroscience 2013 14:65 doi:10.1186/1471-2202-14-65