|Comparison between the main pathology markers in Tg2576 mice chronically treated either with a γ-secretase inhibitor (DAPT) and a mixed γ-secretase modulator with anti-inflammatory properties (CHF5074)|
|Novel object recognition test (recognition index)||unchanged||restored at wild-type level at 375ppm|
|amyloid plaque burden||unchanged||reduced|
|plasma Aβ42||increased||increased at 375ppm|
|microglia activation (Iba1-IR)||unchanged||reduced|
|Dendritic spine density (CA1/2 pyramidal neurons)||restored at wild-type level||increased at 375ppm, compared to Tg2576 vehicle|
|Aberrant cell cycle events (cyclinA-IR neurons)||lightly reduced (−28%)||strongly reduced (−63%)|
Treatments were started in 6month old rats and protracted for 13 months. Behavioral test was then carried out in 18month old animals, and all post-mortem observation in 19month old animals.
Sivilia et al.
Sivilia et al. BMC Neuroscience 2013 14:44 doi:10.1186/1471-2202-14-44