Table 1

Comparison between the main pathology markers in Tg2576 mice chronically treated either with a γ-secretase inhibitor (DAPT) and a mixed γ-secretase modulator with anti-inflammatory properties (CHF5074)
Task/marker DAPT CHF5074
Novel object recognition test (recognition index) unchanged restored at wild-type level at 375ppm
amyloid plaque burden unchanged reduced
oligomers
plasma Aβ42 increased increased at 375ppm
intraneuronal Aβ reduced reduced
microglia activation (Iba1-IR) unchanged reduced
Dendritic spine density (CA1/2 pyramidal neurons) restored at wild-type level increased at 375ppm, compared to Tg2576 vehicle
Aberrant cell cycle events (cyclinA-IR neurons) lightly reduced (−28%) strongly reduced (−63%)

Treatments were started in 6month old rats and protracted for 13 months. Behavioral test was then carried out in 18month old animals, and all post-mortem observation in 19month old animals.

Sivilia et al.

Sivilia et al. BMC Neuroscience 2013 14:44   doi:10.1186/1471-2202-14-44

Open Data