Table 3

Regression formula for hypotheses 1B and 2B
Regression formula for the effect of Strain and Type of middle cerebral artery occlusion procedure on Mortality rate (hypotheses 1B and 2B)
Variable (reference category) Variable categories Regression coefficient 0.95 confidence interval for regression coefficient p-value
Constant NA 17.1 13.9 20.3 0.000
Strain (Sprague Dawley) Wistar 1.0 −2.4 4.4 0.551
SHR −6.9 −12.8 -.87 0.025
WKY −8.3 −19.3 2.8 0.141
Other Strains 4.4 −1.1 9.9 0.113
Type of middle cerebral artery occlusion procedure (Intraluminal filament) Direct, mechanical −10.7 −15.1 −6.2 0.000
Embolic 12.1 6.9 17.3 0.000
Photothrombotic −5.6 −15.3 4.2 0.262
Endothelin injection −9.7 −16.8 −2.6 0.007
Type of anesthetic (Inhalation anesthetic) Chloral Hydrate 4.1 0.17 8.1 0.041
Ketamine 3.2 −1.1 7.4 0.144
Barbiturates and bensodiazepines 1.1 −4.6 6.8 0.710
Other anesthetic 3.0 −1.9 8.0 0.230
Awakening of rats during occlusion (No) [Yes] 9.1 3.9 14.2 0.001
Heart rate monitored (No) [Yes] −3.3 −7.5 0.94 0.127
Blood glucose concentration analyzed (No) [Yes] −2.8 −6.1 0.53 0.099
Type of infarct size evaluation (TTC) Radiology 5.4 −0.11 10.9 0.055
Acidic/Basic stain or silver stain histology −1.2 −4.7 2.4 0.526
Immunohistology 10.4 3.2 17.6 0.005
Criteria for excluding rats (None) Observed absence of cerebral blood flow reduction −4.0 −6.9 −1.1 0.008
Lack of functional deficit 0.15 −3.4 3.7 0.933
Too small infarct 0.22 −5.1 5.6 0.935
Other pathology in animal −3.4 −7.1 0.40 0.079

Variables excluded by statistical software due to too low explanatory value: Sex, Elderly rats, Weight, Intubation, Temperature feedback system, Blood pressure monitored, Blood gases/O2 saturation analyzed, Blood hemoglobin concentration analyzed, Postoperative antibiotics, Occlusion duration, Time after focal ischemia for evaluation of damage, Edema correction used, Blinding of infarct size determination procedure.

Ström et al.

Ström et al. BMC Neuroscience 2013 14:41   doi:10.1186/1471-2202-14-41

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