Table 2

Regression formula for hypotheses 1A and 2A
Regression formula for the effect of Strain and Type of middle cerebral artery occlusion procedure on Infarct size coefficient of variation (hypotheses 1A and 2A)
Variable (reference category) Variable categories Regression coefficient 0.95 confidence interval for regression coefficient p-value
Constant NA 23.1 8.3 38.0 0.002
Strain (Sprague Dawley) Wistar −6.2 −11.5 −0.9 0.023
SHR −1.7 −11.0 7.5 0.710
WKY 19.0 −0.8 38.8 0.059
Other Strains 20.7 10.7 30.8 0.000
Type of middle cerebral artery occlusion procedure (Intraluminal filament) Direct, mechanical 4.2 −3.4 11.8 0.274
Embolic 14.7 3.4 26.0 0.011
Photothrombotic 10.1 −5.2 25.5 0.196
Endothelin injection 23.1 9.3 36.9 0.001
Sex (Male) Female −0.6 −19.7 18.5 0.951
Ovx female 2.3 −16.7 21.4 0.810
Mix or not specified −11.5 −21.5 −1.5 0.024
Elderly rats [Yes] −23.6 −39.6 −7.7 0.004
Weight [Continuous; Grams] 0.1 0.0 0.1 0.001
Type of anesthetic (Inhalation anesthetic) Chloral Hydrate −11.5 −16.9 −6.1 0.000
Ketamine 2.9 −4.4 10.2 0.430
Barbiturates and bensodiazepines −8.4 −17.6 0.9 0.076
Other anesthetic −13.6 −22.6 −4.6 0.003
Awakening of rats during occlusion (No) [Yes] 8.8 0.9 16.7 0.028
Temperature feedback system (No) [Yes] −6.9 −12.4 −1.5 0.013
Blood hemoglobin concentration analyzed (No) [Yes] 10.9 3.0 18.8 0.007
Occlusion duration (Short transient) Long transient 1.9 −3.9 7.8 0.519
Permanent −16.6 −24.1 −9.1 0.000
Time after focal ischemia for evaluation of damage [Continuous; Hours] 0.0051 0.0005 0.0096 0.030
Criteria for excluding rats (None) Observed absence of cerebral blood flow reduction −7.7 −12.4 −2.9 0.002
Lack of functional deficit −2.9 −8.6 2.7 0.310
Too small infarct 0.1 −9.6 9.9 0.981
Other pathology in animal 18.6 12.7 24.6 0.000

Variables excluded by statistical software due to too low explanatory value: Intubation, Postoperative antibiotics, Blood pressure monitoring, Heart rate monitoring, Blood gases/O2 saturation analyzed, Blood glucose concentration analyzed, Type of infarct size evaluation, Edema correction used, Blinding of infarct size determination procedure.

Ström et al.

Ström et al. BMC Neuroscience 2013 14:41   doi:10.1186/1471-2202-14-41

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