Examination of the relationships between AMPA/KA receptors, ROS and WDR35. Rats were administered glutamate receptor antagonists (3 mg/kg, i.p.) or edaravone (10 mg/kg, i.p.) at 1 hour before intraperitoneal administration of DA. WDR35 protein expression at 24 hours after DA administration in hippocampal samples from rats pretreated with (A) NBQX (AMPA/KA receptor antagonist), (B) MK-801 (NMDA receptor antagonist), or (C) edaravone (Ed, radical scavenger) was analyzed by western blotting. *P < 0.05, **P < 0.01 and ***P < 0.001 (n = 4).
Tsunekawa et al. BMC Neuroscience 2013 14:4 doi:10.1186/1471-2202-14-4