Duration of acute CBF drop during SAH determines delayed neurological deficits, CBF reduction and mortality. (A) CBF measured by the 14C-iodoantipyrine method at 3 days after surgery in sham-operated rats, SAH-induced rats with prolonged acute CBF drop and SAH-induced rats with short acute CBF drop. (B) Rotating pole scores obtained at 3 days after surgery by sham-operated rats, SAH-induced rats with short acute CBF drop and SAH rats with prolonged acute CBF drop. (C) CBF-AUC20 min values for animals surviving until termination at 4 days post-SAH (4 days survivors) and animals that died at 3-4 days post-SAH (4 days dead), respectively. All data are means ± s.e.m. *: p < 0.05, **: p < 0.01 as determined by student’s t-test.
Povlsen et al. BMC Neuroscience 2013 14:34 doi:10.1186/1471-2202-14-34