Effect of leaky channel attributed to PSEN1 on calcium oscillations. (a) Perturbation in rate constant kleakPSEN1, over 0.05-0.3 s-1 range affects amplitude and frequency of calcium oscillations in cytoplasm, mitochondria and ER. Absence of leaky current shows increase in ER and mitochondrial Ca2+ concentration (red line) whereas increase in leaky current decreases amplitude and increases frequency (brown line, 0.3 s-1) in cytoplasm. (b) Phase diagram between cytoplasmic and ER calcium store shows loss of regulation of calcium between two organelles. (c) Similarly, breakdown of ER-mitochondria Ca2+ control with increase in leaky current, is observed in ER-mitochondria phase diagram. The color scale for kleakPSEN1 is shown on the bottom right.
Vasaikar et al. BMC Neuroscience 2013 14:3 doi:10.1186/1471-2202-14-3