Expression profiles of neuro-inflammation related genes. Semi-quantitative RT-PCR was used to detect mRNA levels of APP, BACE, PSEN2, p53 and sirt-2. A-Our results indicate that AlCl3 administration induces elevation in APP, BAC and p53 levels at week four (group2a), while resv treatment (group 2b) caused marked reduction in all parameters mRNA levels compared to self-recovery group (2a at week 8). Co-administration of resv during AlCl3 induction and for four weeks later ameliorated neurotoxicity by reducing mRNA levels of pro-inflammatory genes as shown in group3b at weeks 4 and 8. Moreover PSEN2 expression is induced in resv treated groups 2b and 3b. B- Resveratrol induces Sirt-2 in mock-treated group and resveratrol treatment of AlCl3-induced group induces sirt-2 expression as well.
Zaky et al. BMC Neuroscience 2013 14:26 doi:10.1186/1471-2202-14-26