Brain AST activity and Aβ 40 level. A- alterations in brain tissues AST activities (mid brain) indicating significant reduction during the four weeks of AlCl3 administration compared to control (P < 0.01). Pre- and continuous resveratrol administration ameliorated toxicity by maintaining tissue integrity and hence elevated AST activity. B- Aβ 40 concentration significant reduced in AlCl3-induced versus resv-treated rats. Pre-and continuous resveratrol significantly (p < 0.01) maintained high Aβ 40 level upon AlCl3 administration.
Zaky et al. BMC Neuroscience 2013 14:26 doi:10.1186/1471-2202-14-26