MnTBAP versus MP on locomotor recovery following SCI as assessed by the BBB-test and inclined plane test. The spinal cords of rats were injured at vertebra T10 (25 g.cm) using the NYU device. The behavioral tests were performed on animals treated with MnTBAP (ip), MPSS (iv), saline (ip), and a sham control group as described in the Methods section. The first dose of MnTBAP (10 mg/kg) or MPSS (30 mg/kg) were given at 4 h post-SCI and followed by one half of the first dose 2 h later. All experiments were triple blinded. A. results of BBB-test. B. results of inclined plane test. Error bars: mean ± SEM. Clearly, MnTBAP more effectively attenuates the neurological deficits on both tests than does MP.
Liu et al. BMC Neuroscience 2013 14:23 doi:10.1186/1471-2202-14-23