Brain histopathological changes after intracerebral inoculation of 104 PFU of HSV-1 in WT and CCR5-/- mice, at 1 dpi. H&E-stained sections of meninges and cerebral cortex. Meninges of non-infected WT mouse (A) and CCR5-/- animal (D) with normal brain tissue (n = 3 in each group); WT infected animal showing infiltration of immune cells in the meninges (B-C); Intense meningitis characterized by infiltration of polimorphonuclear and mononuclear in CCR5-/- mouse (E-F). A-B: ×200; D-E: ×100; C-F: ×400.
Vilela et al. BMC Neuroscience 2013 14:19 doi:10.1186/1471-2202-14-19