IGF-I Levels Following Hypoxic-Ischemic Injury. IGF-I levels of sham animals are not significantly different between the left and the right hemispheres for the brain regions analyzed (A, C). IGF-I is detectable in the olfactory bulb, but not the cortex (24 h, 72 h) and cerebellum (72 h) of the sham animals (A, C). IGF-I levels are highest in the olfactory bulb and detectable in the penumbra and core 24 h post-stroke (B). At 72 h IGF-I levels are significantly higher in the core region (†) when compared to the other brain regions (D). For statistical analysis, for each brain region, IGF-I levels of the two hemispheres were compared. (*) on the graphs denotes the brain regions where the statistical analysis revealed a significant difference between the stroke and the contralateral hemisphere. Results are mean ± S.D. n = 5; *p < 0.05 by ANOVA contralateral hemisphere vs. stroke hemisphere and †p < 0.05 by ANOVA core versus olfactory bulb, penumbra, cerebellum.
Fletcher et al. BMC Neuroscience 2013 14:158 doi:10.1186/1471-2202-14-158