Visualization of the stroke core and penumbra. The stroke core is defined as the areas where perfusion is completely absent during occlusion, resulting in dead tissue. The stroke penumbra on the other hand receives limited perfusion during occlusion and still contains viable cells that are the main target of neuroprotectants. The drawing (left) shows how tissue collection was carried out. The squares on the drawing indicate the areas for penumbra collections (which correspond to the pink rim outlined in blue in the TTC image); the area inside the squares is the area used for stroke core collections (corresponding to the white area in the TTC image).
Fletcher et al. BMC Neuroscience 2013 14:158 doi:10.1186/1471-2202-14-158