Figure 3.

Sensorimotor functions of wild-type, E10+/− and E10−/− mice. (A) Mice devoid of tau exon 10 (E10−/−) showed no deficits in rotarod when they were 5–6 months-old (E10+/+, n = 19; E10+/−, n = 17; E10−/−; n = 17), (B) but when compared to wild-type (E10+/+, p < 0.05) and E10+/− (p < 0.01) their performance was impaired when they were 13–17 months-old (E10+/+, n = 18; E10+/−, n = 16; E10−/−; n = 15). (C) 5–6 months-old wild-type mice (E10+/+) were weaker than E10+/− (p < 0.05: E10+/+, n = 9; E10+/−, n = 8; E10−/−; n = 8), (D) while 13–17 months-old E10−/− mice were weaker than E10+/− (p < 0.05). *p < 0.05; **p < 0.01.

Gumucio et al. BMC Neuroscience 2013 14:148   doi:10.1186/1471-2202-14-148
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