Table 1

Genes with strong links to autism found in significant postpartum LS expression changes
Gene symbol Gene name Autism databases
Foxp2 Forkhead box P2 7
Sez6l2 Seizure related 6 homolog like 2 7
Lamb1 Laminin B1 7
Slc1a1 Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 7
Adora2a Adenosine A2a receptor 6
Gabra4 Gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 5
Hras1 Harvey rat sarcoma virus oncogene 1 5
Arnt2 Aryl hydrocarbon receptor nuclear translocator 2 5
Lrfn5 Leucine rich repeat and fibronectin type III domain containing 5 4
Scn1a Sodium channel, voltage-gated, type I, alpha 4
Drd2 Dopamine receptor D2 4
Nostrin Nitric oxide synthase trafficker 4
Npy Neuropeptide Y 4
Snrpn Small nuclear ribonucleoprotein N 4
Fabp5 Fatty acid binding protein 5, epidermal 4
Pcdh10 Protocadherin 10 4
Kcnd2 Potassium voltage-gated channel, Shal-related family, member 2 3
Upp2 Uridine phosphorylase 2 3
Rbfox1 RNA binding protein, fox-1 homolog (C. elegans) 1 3
Adra2a Adrenergic receptor, alpha 2a 3
Cadps2 Ca2 + −dependent activator protein for secretion 2 3
Camk2b Calcium/calmodulin-dependent protein kinase II, beta 3
Csmd3 CUB and Sushi multiple domains 3 3
Drd1a Dopamine receptor D1A 3
Fabp7 Fatty acid binding protein 7, brain 3
Foxo1 Forkhead box O1 3
Hcrtr1 Hypocretin (orexin) receptor 1 3
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 3
Mchr1 Melanin-concentrating hormone receptor 1 3
Nr2e1 Nuclear receptor subfamily 2, group E, member 1 3
Oprk1 Opioid receptor, kappa 1 3
Pde4b Phosphodiesterase 4B, cAMP specific 3
Ppp1r1b Protein phosphatase 1, regulatory (inhibitor) subunit 1B 3
Rarb Retinoic acid receptor, beta 3
Robo2 Roundabout homolog 2 (Drosophila) 3
Tac1 Tachykinin 1 3

All genes in Table 1 have expression changes with FDR-adjusted p-values less than 0.25. The farthest right hand column shows the number of autism databases in which the gene was featured, and represents a putative strength of evidence for a positive association to autism. Only genes that appeared in three or more lists are shown here. A full list of autism-associated genes from all databases found in postpartum LS expression changes is provided in Additional file 2: Table S2.

Eisinger et al.

Eisinger et al. BMC Neuroscience 2013 14:147   doi:10.1186/1471-2202-14-147

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