MSET evaluation of enrichment for autism-associated genes within expression data from Tbr1 null mouse neocortex. Y-axis represents the probability of X matches to database found in a randomly generated set of simulated results from the microarray background. The yellow arrow shows how many matches were found in the actual significant Tbr1 null expression changes and where that number falls on the probability density distribution. The enrichment p-value is derived from the number of simulated results that contained at least as many matches to database as the actual results.
Eisinger et al. BMC Neuroscience 2013 14:147 doi:10.1186/1471-2202-14-147