MnTBAP protection against apoptotic cell loss following SCI. MnTBAP (10 mg/kg, ip) was administered as in Figures 7 and 8 and the rats were sacrificed at 24 h post-SCI. The number of TUNEL-positive cells was counted in the gray matter in the sections at 0 – 4 mm rostral from the epicenter at 1 mm intervals. The counts in MnTBAP-treated sections were compared with those in vehicle-treated sections. * indicates a significant difference between the MnTBAP-treated and the vehicle-treated groups (P < 0.05). Error bars, mean ± SEM. Compared to vehicle-treated rats, 10 mg/kg MnTBAP significantly reduced the number of TUNEL-positive cells.
Ling et al. BMC Neuroscience 2013 14:146 doi:10.1186/1471-2202-14-146