The temporal and spatial profiles of cell death after SCI. Cells in the CV-stained sections caudal from the epicenter as shown in Figure 1 in injured or sham control sections were counted as described in the Methods and counts were then statistically compared over time and by distance from the epicenter. The counts were presented as mean ± SD. A: The temporal and spatial profile of motoneuron loss in the ventral gray matter of the cord after SCI. The number of surviving motoneurons increased with the distance from the epicenter at each time point, and decreased over time at each distance after SCI. All significant differences were indicated under the dotted lines. B: The temporal and spatial profiles of glial cell loss in the ventromedial white matter following SCI. Significant glial loss in the white matter was found only near the epicenter; such loss was not significant at 2 mm from the epicenter at any time post-SCI. * indicates significant difference between sham control and SCI (p < 0.05).
Ling et al. BMC Neuroscience 2013 14:146 doi:10.1186/1471-2202-14-146