MnTBAP protection against functional deficits following SCI. The spinal cords of rats were injured at vertebra T10 (12.5 g.cm) using the NYU device. The behavioral tests were performed on animals treated with MnTBAP and saline, and on sham control animals as described in the Methods. MnTBAP (10 mg/kg) or saline was given by i.p. injection at 15 min pre- and 4 h post-SCI for behavioral tests. All experiments were triple blinded. A: results of the BBB test. B: results of the beam walk test. C: results of the inclined plane test. Clearly, MnTBAP treatment significantly improved the functional recovery following SCI relative to the vehicle-treated animals in all three tests. Error bars: mean ± SEM. * indicates a significant difference between the groups of injured with vehicle-treated and the sham controls. # indicates a significant difference in the injured groups between vehicle-treated and MnTBAP-treated.
Ling et al. BMC Neuroscience 2013 14:146 doi:10.1186/1471-2202-14-146