Erk antagonists inhibit DA induced increase in IA Gmax. A. Erk antagonists were applied with and without DA for 1 hr to an ongoing rhythm, followed by 1 hr of blocking saline and TEVC. Erk antagonists were applied 10 min prior to DA application. B. 50 μM PD98059 blocked the DA induced increase in IA Gmax. C. 50 μM U0126 also blocked the DA induced increase in IA Gmax. These data show that Erk is necessary to produce the persistent DA effect. Both data sets were analyzed by ANOVA, with Dunnet’s post hoc tests that compared each treatment group to control and plotted as mean ± S.D.
Rodgers et al. BMC Neuroscience 2013 14:143 doi:10.1186/1471-2202-14-143