Comparison of the basic-model fluxes. The diagram shows the results of four flux balance analyses of the basic dopaminergic nerve cell. As target functions, the maximization of apoptosis (maxApo), the minimization of apoptosis (minApo), the maximization of degradation (maxDeg), and the minimization of degradation (minDeg) were optimized, respectively. Interestingly, the mitochondrial production of ROS by complex I and the apoptosis initiated by LB can be observed only in the maxApo analysis. Mitophagy is performed in minApo and maxDeg, whereas the biogenesis is only performed in maxApo and minDeg. Degradation processes appear mainly in the minApo and maxDeg analysis but are extremely diminished or nonexistent in the maxApo and minDeg analyses.
Büchel et al. BMC Neuroscience 2013 14:136 doi:10.1186/1471-2202-14-136