Ubiquitin, and α-synD135 colocalize with PS129α-syn in hA30Pα-syn mice, regardless of parkin expression status. Analysis by confocal microscopy, showing the degree of colocalization between (A) PS129α-syn and ubiquitin, (B) PS129α-syn and α-synD135, and (C) ubiquitin and α-synD135, in coronal brain sections from a representative symptomatic hA30Pα-syn mouse; similar observations were made in hA30Pα-syn mice with two or no functional parkin alleles (bregma -5.8). The projection stacks correspond to sections of single immunostained cell bodies (upper panels) and processes (lower panels) following the horizontal or vertical dashed line in the Z-stack. Scale bars = 10 μm.
Fournier et al. BMC Neuroscience 2013 14:135 doi:10.1186/1471-2202-14-135