Table 1

Contractile effects of ET-1, U46619, Ang II and 5-CT in human cerebral arteries
N K+ mean ± s.e.m Emax (%) ± s.e.m pEC50 ± s.e.m
ET-1
Control 6 6.76 ± 1.32 107 ± 12a 7.20 ± 0.89
Organ Culture 6 4.37 ± 1.21 143 ± 22 a,b 8.74 ± 0.25
Organ Culture + U0126 7 3.53 ± 0,90 57 ± 8 b 8.49 ± 0,10
U46619
Control 7 8.26 ± 1.98 102 ± 15a 7.35 ± 0.74
Organ Culture 7 5.10 ± 1.60 141 ± 11a,b 7.18 ± 0.18
Organ Culture + U0126 4 3.65 ± 1.89 76 ± 40b 6.64 ± 0.10
Ang II
Control 6 1.67 ± 0.54 12 ± 2a
Organ Culture 5 4.44 ± 1.92 43 ± 12a,b 9.15 ± 0.82
Organ Culture + U0126 4 4.46 ± 2.41 1 ± 1b 9.05 ± 1.13
5-CT
Control 6 6.76 ± 1.36 50 ± 8 7.45 ± 0.66
Organ Culture 4 3.90 ± 1.59 17 ± 5b 7.35 ± 1.21
Organ Culture + U0126 7 3.53 ± 0.90 2 ± 1b 7.38 ± 0.73

Responses were characterized by Emax values, expressed as percent of 63 mM K+ -induced contraction, and pEC50 values (negative logarithm of the molar concentration that produces half maximum contraction). Values are represented as mean ± s.e.m and n represents number of patients. a = significant difference between organ culture and control groups, b = significant difference between organ culture and organ culture treated with U0126.

Ansar et al.

Ansar et al. BMC Neuroscience 2013 14:12   doi:10.1186/1471-2202-14-12

Open Data