Figure 9.

The expression of pro-caspase protein casepase-3 in PC12 cells and ischemic penumbra. (A) Pre-treatment with 10 nM or 20 nM E2 significantly attenuated OGD-R-induced the expression of pro-apoptotic protein caspase-3 (*p <0.05, v.s. DMSO group). Pre-treatment with 10 μM or 20 μM E2 increased the expression of caspase-3 (*p < 0.05, **p < 0.01, v.s. DMSO group). (B) OVX significantly increased the expression of caspase-3 in the ischemic penumbra (**p < 0.01, v.s. the control group). Treatment with 6 μg/kg or 20 μg/kg E2 significantly reduced the expression of caspase-3 (# p < 0.05, v.s. the OVX group). Treatment with 50 μg/kg E2 significantly increased the expression of caspase-3 (**p < 0.01, v.s. control group and 6 μg/kg or 20 μg/kg E2 replacement group).

Ma et al. BMC Neuroscience 2013 14:118   doi:10.1186/1471-2202-14-118
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