The infarct volume in rats exposed to ischemia–reperfusion injury by MCAO receiving different doses of E2. (A) The OVX group resulted in larger infarct volume compared to the control group. 6 μg/kg and 20 μg/kg E2 replacement significantly decreased the infarct volume. 50 μg/kg E2 replacement group resulted in larger infarct volume than the control group and 6 μg/kg or 20 μg/kg E2 replacement group. (**p < 0.01 v.s. the control group, #p < 0.05 v.s. the OVX group, *p < 0.05 v.s. the control group and 6 μg/kg or 20 μg/kg E2 replacement group). (B) Representative photographs showing infarct volume in the different groups after the MACO.
Ma et al. BMC Neuroscience 2013 14:118 doi:10.1186/1471-2202-14-118