The effects of different doses of E2 on cultured PC12 cell morphology. PC12 cells treated with 10 nM or 20 nM E2 exhibited a marked increase in cell number. PC12 cells treated with 10 μM or 20 μM E2 (especially in the 20 μM group) exhibited a marked decrease in cell number with most cells losing their neurites and appearing round. Scale bar = 100 μM.
Ma et al. BMC Neuroscience 2013 14:118 doi:10.1186/1471-2202-14-118