Immunolabeling of cutaneous nerve fibers using Nav 1.7 antibodies in different skin areas in the sole and dorsum of the foot. The intra epidermal nerve fibers (IENF) were less abundant in the sole (A,C,E) than in the dorsum (G). Intrapapillary nerve fibers (IPNF) were observed at all sites (B,D,F,H). There were several sections where no IENFs were observed in the sole, while IENFs were present in the dorsum in most sections. IENFs were not observed in the heel. Arrowheads indicate examples of IENFs. Arrows indicate examples of IPNFs. SC: stratum corneum, Epi: Vital epidermis, Der: Dermis. The dashed lines indicate the dermo-epidermal junction.
Frahm et al. BMC Neuroscience 2013 14:116 doi:10.1186/1471-2202-14-116