Figure 5.

Fluorescence microscopy of neuronal and microglial cells derived from dividing progenitors. Panel A is a confocal photomicrograph that shows NeuN+ (red) cells in the cortex of a control mouse brain for the striatal line. Panel B is a confocal photomicrograph that shows a BrdU+ (green) cell in the same field. Panel C represents the merging of panels A and B, and indicates that the cell (arrow) is NeuN+/BrdU+ (yellow) and therefore represents a neuron derived from a dividing progenitor cell. Scale bar in panels A, B and C represents 12 μm. Panel D is a confocal photomicrograph that shows Iba1+ (red) cells in the striatum of a mutant mouse brain from the striatal line. Panel E is a confocal photomicrograph that shows BrdU+ (green) cells in the same field. Panel F represents the merging of panels D and E and indicates that one cell (arrow) is Iba1+/BrdU+ (yellow) and therefore represents a microglial cell derived from a cell that has undergone cell division. Scale bar in panels D, E and F represents 15 μm.

Smardencas et al. BMC Neuroscience 2013 14:111   doi:10.1186/1471-2202-14-111
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