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Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases

Arthur Smardencas1, Kerelos Rizkalla1, Hyun Ah Kim12, Jim Massalas1, Claire O’Leary13, Michelle E Ehrlich4, Günter Schütz5, Andrew J Lawrence1 and John Drago1*

Author Affiliations

1 Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia

2 Current address: Department of Pharmacology, Monash University, Clayton, Victoria, Australia

3 Molecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin, Ireland

4 Department of Neurology, Mount Sinai School of Medicine, New York, USA

5 Deutsches Krebsforschungszentrum, Heidelberg, Germany

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BMC Neuroscience 2013, 14:111  doi:10.1186/1471-2202-14-111

Published: 3 October 2013

Additional files

Additional file 1: Figure S1:

Fluorescence microscopy highlighting densely packed Drd1a-GFP-positive cells in the dorsomedial striatum. Photomicrograph of striatal line Drd1a-GFP WT control mouse brain (GFP cells labeled green) (A) and striatal line mutant mice on a GFP genetic background (B). Drd1a-GFP-positive cells are abundantly expressed throughout the striatum in the GFP-control mouse brain and significantly lost in GFP-striatal mouse brain. Dotted line outlines the dorsomedial striatum that remains relatively densely packed with Drd1a-GFP-positive cells in both lines. Scale bar = 100 μm.

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