|Genotypes of transgenic animals|
Overview of used genotypes and nomenclature of ETNA models. Wildtype (wt), heterozygous (het), and homozygous (hom) animals of single transgenic E5 and E8 models were used.
For the double transgenic E85 model, the E8 and E5 models were crossbred and only double heterozygous (het/het) and wildtype (wt/wt) animals were used.
E8 and E85 animals were intercrossed with hQC animals to generate multi-tg ETNA-hQC animals. In these models the genotype of the hQC allele is always indicated last.
For the double transgenic E8-hQC model, In E8-hQC the E8 allele was always homozygous in hom/wt, hom/het, and hom/hom animals and wildtype (wt/wt) animals were used as control.
For the triple transgenic E85-hQC model the E8 and E5 alleles were always double heterozygous (het/het) and wt, and hom of the hQC allele was used.
Becker et al.
Becker et al. BMC Neuroscience 2013 14:108 doi:10.1186/1471-2202-14-108