QC overexpression. Double immunofluorescent labeling of hom/hom E8-hQC animals revealed human QC specific immunoreactivity (red) colocalized with pE3-Aβ (green) in the striatum (A). Analysis of QC activity at the age of 6 months revealed an indistinguishable activity for ETNA animals compared to wt animals and a ~60-fold increase for het and ~100-fold increase for hom overexpression of hQC (B); data were analyzed by one-way ANOVA followed by Newman-Keuls post-hoc test and represent means ± SEM; *** p < 0.01; n = 2–12 animals per group.
Becker et al. BMC Neuroscience 2013 14:108 doi:10.1186/1471-2202-14-108