Table 4

Disease characterization of coexpression modules in each network
Control Network
Module Theme Module No. Module Size SZUP Overlap SZDOWN Overlap
(25 genes) (73 genes)
Oxidative phosphorylation CTL24 1996 0 34***
Glutamine metabolism CTL20 504 7*** 0
Myelination CTL25 749 2 0
Immune response CTL1 329 3** 0
Synaptic transmission CTL18 291 0 10***
Schizophrenia Network
Module Theme Module No. Module Size SZUP Overlap SZDOWN Overlap
(25 genes) (73 genes)
Oxidative phosphorylation SZ3 1144 0 34***
Glutamine metabolism SZ9 717 12*** 1
Myelination SZ20 711 2 0
Immune response SZ15 198 0 0
Ubiquitination SZ2 1424 0 12

The top five modules in each network were characterized by enrichment of genes that are differentially expressed in schizophrenia. Module themes were assigned based on Gene Ontology enrichment analysis. Disease effect p-values were computed by entering the t-statistic for the disease effect of each gene into a Wilcoxon rank-sum test by module. For all modules listed the disease effect p-values are p < << 0.001 and values can be found in the supplement. SZUP and SZDOWN are the up- and down-regulated schizophrenia gene sets previously identified in our meta-analysis [2]. **p < 0.01; ***p < < 0.001.

Mistry et al.

Mistry et al. BMC Neuroscience 2013 14:105   doi:10.1186/1471-2202-14-105

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