Table 2

Monoamines and their metabolites in the cortex and striatum of mGlu2−/− and mGlu3−/− mice and their respective wild-type (WT) littermates
mGlu2 WT mGlu2−/− mGlu3 WT mGlu3−/−
Cortex
Dopamine 0.5 +/− 0.08 0.4 +/− 0.07 0.4 +/− 0.04 0.4 +/− 0.05
DOPAC 0.2 +/− 0.03 0.2 +/− 0.01 0.2 +/− 0.02 0.2 +/− 0.03
Noradrenaline 2.0 +/− 0.18 1.8 +/− 0.16 2.2 +/− 0.19 2.3 +/− 0.22
MHPG 0.6 +/− 0.05 0.6 +/− 0.05 0.7 +/− 0.10 0.8 +/− 0.07
5-HT 3.1 +/− 0.19 3.1 +/− 0.23 3.1 +/− 0.20 2.9 +/− 0.25
5-HIAA 1.0 +/− 0.03 0.8 +/− 0.06 0.8 +/− 0.08 0.7 +/− 0.06
Striatum
Dopamine 34.0 +/− 3.8 36.5 +/− 3.8 35.7 +/− 4.7 32.6 +/− 3.3
DOPAC 2.3 +/− 0.2 2.4 +/− 0.2 2.1 +/− 0.1 2.2 +/− 0.2
HVA 2.8 +/− 0.2 3.1 +/− 0.2 2.3 +/− 0.2 3.0 +/− 0.3
Noradrenaline 2.0 +/− 0.2 1.8 +/− 0.2 1.5 +/− 0.1 1.6 +/− 0.1
5-HT 2.9 +/− 0.2 3.1 +/− 0.2 3.6 +/− 0.2 3.5 +/− 0.3
5-HIAA 1.6 +/− 0.1 1.6 +/− 0.1 1.6 +/− 0.1 1.8 +/− 0.03

n=6-8 in each group. Values are pmol/mg tissue, mean ± SEM. There are no significant differences between groups. Reliable measurements for cortical HVA and striatal MHPG could not be obtained.

Lane et al.

Lane et al. BMC Neuroscience 2013 14:102   doi:10.1186/1471-2202-14-102

Open Data