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This article is part of the supplement: Twenty First Annual Computational Neuroscience Meeting: CNS*2012

Open Access Poster presentation

Comparing the spatio-temporal organization of joint spiking and local field potential oscillations in motor cortex

Michael Denker1*, Lyuba Zehl1, Thomas Brochier2, Alexa Riehle24 and Sonja Grün134

Author Affiliations

1 Institute of Neuroscience and Medicine (INM-6), Forschungszentrum Jülich, Germany

2 Institut de Neurosciences de la Timone (INT), UMR 7289, CNRS - Aix Marseille Univ., Marseille, France

3 Theoretical Systems Neurobiology, RWTH Aachen University, Germany

4 RIKEN Brain Science Institute, Wako-shi, Japan

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BMC Neuroscience 2012, 13(Suppl 1):P127  doi:10.1186/1471-2202-13-S1-P127


The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2202/13/S1/P127


Published:16 July 2012

© 2012 Denker et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Poster presentation

Oscillations of the local field potential (LFP) are regarded as a signature of synchronized activity in neuronal networks. In primary motor (MI) and premotor (PM) cortex, LFPs typically exhibit such oscillatory activity in the beta range (15–30Hz) during an instructed delay [1]. These oscillations tend to display a wave-like propagation across the cortical surface [2]. In parallel, temporally precise, behavior-related spike synchronization is often observed during periods of movement preparation and expectation [3]. In a previous study we demonstrated that the occurrence of significant spike coincidences is dependent on the phase of LFP beta oscillations [4]. In order to extend these studies to include positional information, we here study how the spatio-temporal organization of the LFP activity across cortical distances of several millimeters is related to that of spike synchronization [5].

Two monkeys were trained to press a switch with one hand, and then to grasp and pull an object using either a Side Grip or a Precision Grip. The force on the object could be either low or high. In order to allow the monkey to prepare the movement, the grip type was revealed at the beginning of an instructed delay of 1 s before the GO signal. In contrast, the force information was encoded by the GO signal itself. LFP and single unit activity was recorded simultaneously from a 100 electrode Utah array implanted at the MI/PMd border.

We analyze oscillatory activity in the beta band with respect to grip type and cortical position. Based on the phase synchrony of LFPs across electrodes, we quantify the spatial inhomogeneity of LFP propagation by its direction and speed in a time-resolved manner. In parallel, we compute spike correlations that significantly exceed chance level [5] as a function of temporal, spatial, and directional parameters. We find that the likelihood of synchronized spiking is behaviorally modulated in time, and decreases with distance between the two recorded neurons. Finally, we compare the spatial distribution of spike synchrony (represented as a graph of neurons exhibiting significant spike coincidences), and synchrony expressed by LFP oscillations in different epochs of the experimental paradigm.

Acknowledgments

Helmholtz Alliance on Systems Biology, European Union (FP7-ICT-2009-6, BrainScales), DAAD, Neuro_IC2010, CNRS-PEPS.

References

  1. Kilavik BE, Ponce-Alvarez A, Trachel R, Confais J, Takerkart S, Riehle A: Context-Related Frequency Modulations of Macaque Motor Cortical LFP Beta Oscillations.

    Cereb Cortex 2011.

    doi:10.1093/cercor/bhr299

    OpenURL

  2. Rubino D, Robbins KA, Hatsopoulos NG: Propagating Waves Mediate Information Transfer in the Motor Cortex.

    Nat Neurosci 2006, 9:1549-1557. PubMed Abstract | Publisher Full Text OpenURL

  3. Riehle A, Diesmann M, Grün S, Aertsen A: Spike Synchronization and Rate Modulation Differentially Involved in Motor Cortical Function.

    Science 1997, 278:1950-1953. PubMed Abstract | Publisher Full Text OpenURL

  4. Denker M, Roux S, Lindén H, Diesmann M, Riehle A, Grün S: The Local Field Potential Reflects Surplus Spike Synchrony.

    Cereb Cortex 2011, 21:2681-2695. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  5. Grün S, Diesmann M, Aertsen A: Unitary Events in Multiple Single-Neuron Spiking Activity: I. Detection and Significance.

    Neural Comp 2002, 14:43-80.

    Grün S, Diesmann M, Aertsen A: Unitary Events in Multiple Single-Neuron Spiking Activity: II. Nonstationary Data. Neural Comp 2002, 14:81-119.

    Publisher Full Text OpenURL