Brain activation for the significant interaction between group and presentation condition. Weaker activation was found in the autism spectrum disorders (ASD) group than in the control (CON) group for dynamic (DY) versus static (ST) expressions. A. Statistical parametric maps rendered on spatially normalized brains. A height threshold of p < .01 (uncorrected) was used without extent threshold restriction for display purposes. L = Left hemisphere; R = Right hemisphere. B. Statistical parametric maps of representative brain regions overlaid on the normalized anatomical MRI of one of the participants in this study. From left to right, the activation of the middle temporal gyrus (MTG; x 52, y -62, z 0; t = 5.08), fusiform gyrus (FG; x 40, y -58, z -14; t = 3.00), amygdala (AMY; x -28, y -4, z -18; t = 2.89), medial prefrontal cortex (MPFC; x 8, y 66, z 20; t = 3.87), and inferior frontal gyrus (IFG; x 48, y 26, z 8; t = 3.06) is shown. The statistical thresholds are the same as above. C. Mean parameter estimates (± SE) of brain regions corresponding to the above overlaid MRIs. The data were extracted at the sites of peaks. FE = Fear; HA = Happiness.
Sato et al. BMC Neuroscience 2012 13:99 doi:10.1186/1471-2202-13-99